Alan D'Andrea, M.D. - The D'Andrea Laboratory
Alan D'Andrea, M.D.
Dana-Farber Cancer Institute
Harvard Medical School
  • HOME
  • RESEARCH
  • LAB MEMBERS
  • PUBLICATIONS
  • CONTACT US
  • FANCONI ANEMIA TESTING
        Selected Publications (from over 200 peer-reviewed publications) 
  1. Kupfer GM, Naf D, Suliman A, Pulsipher M, D’Andrea AD.  The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex.  Nature Genetics 17:487-490, 1997.
  2. Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C. Hejna J, Grompe M, D’Andrea AD.   Interaction of the Fanconi Anemia Proteins and BRCA1 in a common pathway.   Molecular Cell 7:249-262, 2001.
  3. Taniguchi T, Garcia-Higuera I, Xu B, Andreassen P, Gregory RC, Lane WS, Kim S-T, Kastan MB, D’Andrea AD.  Convergence of the Fanconi Anemia and Ataxia Telangiectasia signaling pathways.  Cell 109:459-472, 2002.
  4. Howlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, de Die-Smulders C, Persky N, Grompe M, Joenje H, Pals G, Ikeda H, Fox EA, D’Andrea AD. Biallelic inactivation of BRCA2 in Fanconi Anemia.  Science 297:606-609, 2002.
  5. Taniguchi T, Tischkowitz M, Ameziane N, Hodgson SV, Mathew CG, Joenje H, Mok SC, D’Andrea AD.  Disruption of the Fanconi Anemia/BRCA pathway in cisplatin-sensitive ovarian tumors.  Nature Medicine 9:568-74, 2003
  6. Cohn MA, Kowal P, Yang K, Haas W, Huang T, Gygi SP, D’Andrea AD.  A UAF1-containing multisubunit protein complex regulates the Fanconi Anemia Pathway. MolCell 28:786-797, 2007.
  7. Kee Y, Kim JM, D’Andrea AD.  Regulated Degradation of FANCM in the Fanconi Anemia Pathway during Mitosis. 2009 Genes and Devel. 1:23(5):555-60. PMCID: PMC2658523
  8. D'Andrea AD. Susceptibility pathways in Fanconi's anemia and breast cancer. 2010 N Engl J Med 362: 1909-1919. PMC3069698
  9. Huang M, Kim JM, Shiotani B, Yang K, Zou L, D’Andrea AD.  The FANCM/FAAP24 Complex is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response.  2010 Mol Cell. 39(2):259-68. PMC2928996
  10. Yang K, Moldovan GL, Vinciguerra P, Murai J, Takeda S, D'Andrea AD. Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev. 2011 Sep 1;25(17):1847-58. PMC3175720
  11. Moldovan GL, Dejsuphong D, Petalcorin M, Hofmann K, Takeda S, Boulton S, D’Andrea AD.  Inhibition of homologous recombination by the PCNA-interacting protein PARI.  2012 Molecular Cell 45: 75-86 PMC3267324
  12. Kim H, Yang K, Dejsuphong D, D’Andrea, AD. Regulation of Rev1 by the Fanconi Anemia Core Complex. Nat Struct Mol Biol. 2012 Jan 22;19(2):164-70. PMC3280818
  13. Park E, Kim H, Kim JM, Primack B, Vidal-Cardenas S, Xu Y, Price BD, Mills AA, D’Andrea AD.  FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis. Mol Cell. 2013 Jun 27;50(6):908-18. 
  14. Price BD, D'Andrea AD. Chromatin remodeling at DNA double-strand breaks. Cell. 2013 Mar 14;152(6):1344-54. PMC3670600
  15. Ceccaldi R, Liu J, Amunugama R, Hajdu I, Primack B, Petalcorin MIR, O’Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D’Andrea AD. Homologous recombination (HR)-deficient tumors are hyper-dependent on POLQ-mediated repair. Nature. 2015 Feb 12;518(7538):258-62.


       Selected Reviews

  1. Kim H, D’Andrea AD. Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev. 2012 Jul 1;26(13):1393-408.
  2. Kee, Y, D’Andrea, AD. Molecular Pathogenesis and Clinical Management of Fanconi Anemia, Journal of Clinical Investigation, J Clin Invest. 2012 Nov 1;122(11):3799-806. 
  3. Kee Y, D'Andrea AD. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev. 2010 Aug 15;24(16):1680-94.
  4. Moldovan, G. L. & D'Andrea, A. D. How the Fanconi anemia pathway guards the genome. Annu Rev Genet 43, 223-249 (2009). PMCID: PMC2830711

Click for full Bibliography
Powered by Create your own unique website with customizable templates.